Join us for some great networking, hors d'oeuvres, drinks, and a scientific presentation on Macromolecule Conformational Heterogeneity in CryoEM, to be presented by Steven W. Muchmore, Group Director Structural Biology, at OpenEye, Cadence Molecular Sciences.
Date: December 12, 2024
Location: Boston Marriott Cambridge
Host: BAGIM & OpenEye, Cadence Molecular Sciences
Speaker: Steve Muchmore
Presentation Topic: Macromolecule Conformational Heterogeneity in CryoEM
Event Agenda
5:15 pm - Doors open
6:00 pm - Presentation followed by a Q&A
6:45 pm - Networking
Event is in Salons 1-2 Foyer room at the Marriot.
Discount Parking Stickers for Kendal Center Green Garage (available after 5 PM Mon-Fri or up to 10 hrs. Sat/Sun, Pay On Own, $10 per car after 5 PM). Marriot Valet is $62.
About the presenter
Steve Muchmore heads up the Structural Biology group at OpenEye, Cadence Molecular Sciences. Steve has extensive experience in the use of 3D structural information in pharmaceutical development environments, having spent 25 years in various roles in drug discovery. Initially trained as an x-ray crystallographer, he has been caught up in supporting the emerging field of cryoEM with a particular focus on automating the fitting of models to the cryoEM reconstruction maps.
About the presentation
Structural Biology has undergone a startling revolution in the past ten years or so with the development of cryogenic Electron Microscopy (cryoEM) hardware and software systems that can generate near-atomic resolution structures of biologically relevant macromolecular systems. Sample handling for cryoEM doesn’t require crystallization to enable data collection. This difference can lead to the capture of conformational heterogeneity which potentially can be used in drug discovery efforts. This presentation will discuss methods developed to visualize the structural heterogeneity, both in the generation of the experimental maps and in fitting models to those electron density representations
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