Dr. Alan Rigby, CSO of Warp Drive Bio, will be presenting at Le Meridien Cambridge/MIT in the Taylor room on Tuesday, October 18th. The talk will start at 6pm, and afterwards we will move to Meadhall at 4 Cambridge Center for refreshments.
Please RSVP early and often to help us plan the evening accurately.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Boston Area Group for Informatics and Modeling
Thursday, October 6, 2016
Wednesday, September 14, 2016
BAGIM Event: Dr. Andy Maynard Sept. 26th Starting at 6pm at Vertex
Dr. Andy Maynard of Creode Analytics will present "Lead Optimization
Dynamics" on Monday, September 26th at 7 pm following refreshments at 6
pm on the 9th floor of the Vertex One building at 50 Northern Avenue,
Boston.
Lead optimization (LO) is a challenging team “sport”, involving a diverse team of scientists who strive to efficiently convert early chemical starting points into mature clinical assets. Traditionally, LO has been quantified in terms of static “compound quality” endpoints, without regard to quantifying the dynamical nature of the LO process. Here, we consider LO as a process that minimizes risk, defined in simple statistical terms, to holistically visualize the trajectories of drug discovery projects as a means to objectify LO progress and to define determinants of efficiency. In addition, LO convergence metrics are developed to facilitate comparison of project tractability (for project portfolios).
http://pubs.acs.org/doi/abs/
Vertex is a short 12 minute walk from South Station via Atlantic and Northern Avenues, or take the Silver Line bus from South Station to Court House Station and cross Northern Avenue. Parking is available in the Pilgrim Parking Fan Pier parking garage beneath the building for a flat $15 fee after 5pm. There is also street parking with coin meters and smart meters in the area.
Security procedures and sign-in at Vertex will be accelerated by having your full name. Please add them to your RSVP or email me your full name at bagimcommunications@gmail.com Thank you!
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Lead optimization (LO) is a challenging team “sport”, involving a diverse team of scientists who strive to efficiently convert early chemical starting points into mature clinical assets. Traditionally, LO has been quantified in terms of static “compound quality” endpoints, without regard to quantifying the dynamical nature of the LO process. Here, we consider LO as a process that minimizes risk, defined in simple statistical terms, to holistically visualize the trajectories of drug discovery projects as a means to objectify LO progress and to define determinants of efficiency. In addition, LO convergence metrics are developed to facilitate comparison of project tractability (for project portfolios).
http://pubs.acs.org/doi/abs/
Vertex is a short 12 minute walk from South Station via Atlantic and Northern Avenues, or take the Silver Line bus from South Station to Court House Station and cross Northern Avenue. Parking is available in the Pilgrim Parking Fan Pier parking garage beneath the building for a flat $15 fee after 5pm. There is also street parking with coin meters and smart meters in the area.
Security procedures and sign-in at Vertex will be accelerated by having your full name. Please add them to your RSVP or email me your full name at bagimcommunications@gmail.com Thank you!
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Friday, July 22, 2016
BAGIM Event: Dr. Tzachi Pilpel August 9th starting at 5:45 pm at the Broad
Dr. Tazchi Pilpel of the Weizmann Institute will present "Revealing and Manipulating the Costs of
Gene Expression" on Tuesday, August 9th at 7pm, following refreshments
and networking at 5:45pm, at the Broad Institute, 415 Main St. Cambridge
MA.
Dr. Pilpel's more detailed description of the talk: "Cells invest a significant amount of their energy and other resources to express their proteins. An economic strategy for gene expression would amount to an evolutionary design of genes whose proteins are expressed at a desired level but that minimize consumption of cellular resources during production. I will describe our usage of a synthetic gene approach, combined with in-lab massive competition and deep sequencing to reveal architectures of genes that evolved to minimize gene expression burden while maintaining a desired protein expression level."
Once at the Broad, take the elevators to the second floor, exiting left. The event will be in the Monadnock room. Please RSVP early and accurately so that we may better plan the event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Dr. Pilpel's more detailed description of the talk: "Cells invest a significant amount of their energy and other resources to express their proteins. An economic strategy for gene expression would amount to an evolutionary design of genes whose proteins are expressed at a desired level but that minimize consumption of cellular resources during production. I will describe our usage of a synthetic gene approach, combined with in-lab massive competition and deep sequencing to reveal architectures of genes that evolved to minimize gene expression burden while maintaining a desired protein expression level."
Once at the Broad, take the elevators to the second floor, exiting left. The event will be in the Monadnock room. Please RSVP early and accurately so that we may better plan the event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Thursday, April 14, 2016
BAGIM Event: Dr. Tudor Oprea, May 11th starting at 6pm at the Harvard Faculty Club
Dr. Tudor Oprea of the University of New Mexico will present "Linking Drugs, Diseases, and the Druggable Proteome" at 6pm at the Harvard Faculty Club on Quincy Street in Cambridge, MA on May 11th. A social hour with refreshments will follow at John Harvard's Brewery and Ale House at 33 Dunster St.
Please RSVP early and accurately to help us best plan for our event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Please RSVP early and accurately to help us best plan for our event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Monday, March 28, 2016
BAGIM Event: Dr. Paul Clemons and Dr. Mathias Wawer, April 28th starting at 6pm at the Broad Institute
Dr. Paul Clemons and Dr. Mathias Wawer will present "Chemical diversity expressed through small-molecule performance: diverse readouts, phenotypes, and genetic determinants" on Thursday, April 28, 2016 at 7pm, following refreshments at 6pm, at the Broad Institute, 415 Main St. Cambridge MA.
Once at the Broad, take the elevators to the second floor, exiting left. Food and drink will be in the Yellowstone room, and the presentation in the Monadnock room. Please RSVP early and accurately so that we may better plan the event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Once at the Broad, take the elevators to the second floor, exiting left. Food and drink will be in the Yellowstone room, and the presentation in the Monadnock room. Please RSVP early and accurately so that we may better plan the event.
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Monday, February 22, 2016
Equinox Party and BAGIM Networking Event March 22nd, 2016
Come and celebrate the Spring Equinox with drinks and food at The Asgard Irish Pub & Restaurant Tuesday, March 22nd, from 5-7:30pm. The Asgard is at 350 Massachusetts Avenue, Cambridge, MA. This is a networking event for BAGIM members.
Please note that the guest list for this event is limited to 40 BAGIM members. RSVP here.
We will add additional names on a waiting list after we receive 40 RSVPs. Please be accurate in your replies, and please if your plans change reverse your RSVP so that others can attend.
We're looking forward to seeing you there smile emoticon
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
Thursday, January 14, 2016
BAGIM Event: Dr. Penny Beuning at Vertex, Monday February 1st, starting at 6pm
Dr. Penny Beuning of Northeastern University will present "Specificity of Potentially Mutagenic DNA Polymerases for Different Types of DNA Damage" on Monday, February 1st at 7 pm following refreshments at 6 pm on the 9th floor of the Vertex One building on Northern Avenue. We are planning a larger, non-pizza meal which will include vegetarian options and drinks before the talk.
Please see Dr. Beuning's research lab page
Please RSVP for this event
BAGIM is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger, Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals, the Cambridge Crystallographic Data Centre, Optibrium, Dassault Systemes, Dotmatics, LabAnswer, and ChemAxon
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