Dr. Tazchi Pilpel of the Weizmann Institute will present "Revealing and Manipulating the Costs of
Gene Expression" on Tuesday, August 9th at 7pm, following refreshments
and networking at 5:45pm, at the Broad Institute, 415 Main St. Cambridge
MA.
Dr. Pilpel's more detailed description of the talk: "Cells
invest a significant amount of their energy and other resources to
express their proteins. An economic strategy for gene expression would
amount to an evolutionary design of genes whose proteins are expressed
at a desired level but that minimize consumption of cellular resources
during production. I will describe our usage of a synthetic gene
approach, combined with in-lab massive competition and deep sequencing
to reveal architectures of genes that evolved to minimize gene
expression burden while maintaining a desired protein expression level."
Once at the Broad, take the elevators to the second floor,
exiting left. The event will be in the Monadnock room. Please RSVP early and accurately so that we may better plan the event.
BAGIM
is sponsored by Scilligence, OpenEye Scientific Software, Schrodinger,
Chemical Computing Group, ARIAD Pharmaceuticals, Vertex Pharmaceuticals,
the Cambridge Crystallographic Data Centre, Optibrium, Dassault
Systemes, Dotmatics, LabAnswer, and ChemAxon
Boston Area Group for Informatics and Modeling